Abstract
Natural-product-derived drugs are a major portion of the total number of approved drugs in the antibacterial area. The majority of bacteria and fungi in the environment is only known by molecular fingerprints and has resisted cultivation. Therefore, new methods have been developed to access this tremendous microbial diversity for the discovery of novel small molecules. These culture-dependent and -independent methods include a novel high-throughput cultivation technology as well as a recombinant approach to discover and express novel natural products. © 2005 Humana Press Inc.
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Zengler, K., Paradkar, A., & Keller, M. (2005). New methods to access microbial diversity for small molecule discovery. In Natural Products: Drug Discovery and Therapeutic Medicine (pp. 275–293). Humana Press. https://doi.org/10.1007/978-1-59259-976-9_12
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