Exploiting Aerobic Carboxydotrophic Bacteria for Industrial Biotechnology

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Abstract

Aerobic carboxydotrophic bacteria are a group of microorganisms which possess the unique trait to oxidize carbon monoxide (CO) as sole energy source with molecular oxygen (O2) to produce carbon dioxide (CO2) which subsequently is used for biomass formation via the Calvin-Benson-Bassham cycle. Moreover, most carboxydotrophs are also able to oxidize hydrogen (H2) with hydrogenases to drive the reduction of carbon dioxide in the absence of CO. As several abundant industrial off-gases contain significant amounts of CO, CO2, H2 as well as O2, these bacteria come into focus for industrial application to produce chemicals and fuels from such gases in gas fermentation approaches. Since the group of carboxydotrophic bacteria is rather unknown and not very well investigated, we will provide an overview about their lifestyle and the underlying metabolic characteristics, introduce promising members for industrial application, and give an overview of available genetic engineering tools. We will point to limitations and discuss challenges, which have to be overcome to apply metabolic engineering approaches and to utilize aerobic carboxydotrophs in the industrial environment.

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Siebert, D., Eikmanns, B. J., & Blombach, B. (2022). Exploiting Aerobic Carboxydotrophic Bacteria for Industrial Biotechnology. In Advances in Biochemical Engineering/Biotechnology (Vol. 180, pp. 1–32). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/10_2021_178

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