Effects of ranitidine and metoclopramide on gastric fluid ph and volume in children

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Abstract

To determine the effects of ranitidine and metoclopramide on gastric fluid in children, 40 healthy children (aged 2-8 yr) were allocated randomly to groups of 10 to receive one of four oral premedications 4 h before surgery: no premedication, metoclopramide 0.1 mg kg-1 ranitidine 2 mg kg-1 and metoclopramide 0.1 mg kg-1 with ranitidine 2mg kg-1. After tracheal intubation, gastric fluid was aspirated and analysed for pH and total fluid volume. Ranitidine, with or without metoclopramide, increased gastric fluid pH significantly compared with control (P < 0.05). Gastric fluid volume did not change significantly. © 1990 Copyright: 1990 British Journal of Anaesthesia.

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Christensen, S., Farrow-gillespie, A., & Lerman, J. (1990). Effects of ranitidine and metoclopramide on gastric fluid ph and volume in children. British Journal of Anaesthesia, 65(4), 456–460. https://doi.org/10.1093/bja/65.4.456

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