Background: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. Methods: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. Results and conclusion: Our results in rats thatreceived MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration. © 2008 Elgrabli et al; licensee BioMed Central Ltd.
CITATION STYLE
Elgrabli, D., Floriani, M., Abella-Gallart, S., Meunier, L., Gamez, C., Delalain, P., … Lacroix, G. (2008). Biodistribution and clearance of instilled carbon nanotubes in rat lung. Particle and Fibre Toxicology, 5. https://doi.org/10.1186/1743-8977-5-20
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