0147 Meta-analysis on night shift work and risk of metabolic syndrome

Abstract

ObjectivesThis study aims to quantitatively summarise the association between night shift work and the risk of metabolic syndrome (MetS). MethodWe systematically searched all observational studies published in English on Pubmed and Embase from 1971 to 2013. We extracted effect measures (relative risk, RR; or odd ratio, OR) with 95% confidence interval (CI) from individual studies to generate pooled results using meta-analysis approach. Pooled RR was calculated using random- or fixed effect model. Downs and Black scale was applied to assess the methodological quality of included studies. ResultsA total of 13 studies were included in the meta-analysis. The pooled adjusted RR for the association between "ever exposed to night shift work" and MetS risk was 1.57 (95% CI = 1.24-1.98, pheterogeneity = 0.001). Further stratification analysis for gender, MetS definition and study population demonstrated similar trends. The sensitivity analysis confirmed the stability of the results and no publication bias was detected. ConclusionsThe present meta-analysis suggests that night shift work is significantly associated with the risk of MetS, showing a positive dose-response relationship with the intensity of night shifts. Large-scale well-design prospective studies are required to further investigate the association, especially in Asia countries.[National Natural Science Foundation of China (Project number 81273172 and 81372964), Shelly@cuhk.edu.hk (Lap Ah Tse)]