Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1

46Citations
Citations of this article
121Readers
Mendeley users who have this article in their library.

Abstract

Brief monocular deprivation (MD) shifts ocular dominance and reduces the density of thalamic synapses in layer 4 of the mouse primary visual cortex (V1). We found that microglial lysosome content is also increased as a result of MD. Previous studies have shown that the microglial fractalkine receptor CX3CR1 is involved in synaptic development and hippocampal plasticity.Wetherefore tested the hypothesis that neuron-to-microglial communication via CX3CR1 is an essential component of visual cortical development and plasticity in male mice. Our data show that CX3CR1 is not required for normal development of V1 responses to visual stimulation, multiple forms of experience-dependent plasticity, or the synapse loss that accompanies MD in layer 4. By ruling out an essential role for fractalkine signaling, our study narrows the search for understanding how microglia respond to active synapse modification in the visual cortex.

Cite

CITATION STYLE

APA

Schecter, R. W., Maher, E. E., Welsh, C. A., Stevens, B., Erisir, A., & Bear, M. F. (2017). Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1. Journal of Neuroscience, 37(44), 10541–10553. https://doi.org/10.1523/JNEUROSCI.2679-16.2017

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free