Histopathology and biochemical analysis of common carp (Cyprinus carpio) exposed to sublethal concentrations of carboxin-thiram (Vitavax thiram)

Abstract

This study aimed to investigate histopathological, biochemical and behavioral changes of common carp (Cyprinus carpio) exposed to sublethal concentration of Carboxin-Thiram (Vitavax thiram) for one week in static conditions. Live specimens of C. carpio were obtained and exposed to 5, 15 and 30 mg L -1 carboxin-thiram for one week. There was one control group (no toxicant) and three replicates. The physicochemical properties of water and the following were constant: pH: 8±0.5, temperature: 19±0.4°C, hardness: 345±6 ppm and dissolved oxygen: 7.3±0.3. Results showed the kinds of pathologies such as secondary lamellae shrinking, lamellar fusion, lamellar aneurism, lamellar clubbing and hyperplasia in gills and lipidosis, pyknotic nuclei, atrophy, aggregation of blood cell, hemosiderin and biliary stagnation in liver. Biochemical analysis revealed that total protein and albumin serum decreased and glucose level increased significantly after 7 days exposer. This study revealed the adverse effect of carboxin-thiram in C. carpio for the first time.