Introduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a novel area of research in stroke. Methods: We perform an arginine and human growth hormone releasing hormone challenge on ischemic stroke patients within a week of symptom onset. Results: Over the study period, 13 patients were successfully tested within a week of stroke (baseline NIHSS 10, range 7-16). Overall, 9(69%) patients had a poor response, with 7(54%) of these patients meeting the criteria for had human growth hormone deficiency. Other measures of pituitary function were within normal ranges. Conclusion: After major ischemic stroke, low GH levels are common and may play a role in stroke recovery.
CITATION STYLE
Lillicrap, T., Garcia-Esperon, C., Walker, F. R., Ong, L. K., Nilsson, M., Spratt, N., … Bivard, A. (2018). Growth hormone deficiency is frequent after recent stroke. Frontiers in Neurology, 9(SEP). https://doi.org/10.3389/fneur.2018.00713
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