Biomaterials are a new treatment strategy for cardiovascular diseases but are difficult to deliver to the heart in a safe, precise, and translatable way. We developed a method to deliver hydrogels to the epicardium through the pericardial space. Our device creates a temporary compartment for hydrogel delivery and gelation using anatomic structures. The method minimizes risk to patients from embolization, thrombotic occlusion, and arrhythmia. In pigs there were no clinically relevant acute or subacute adverse effects from pericardial hydrogel delivery, making this a translatable strategy to deliver biomaterials to the heart.
CITATION STYLE
Garcia, J. R., Campbell, P. F., Kumar, G., Langberg, J. J., Cesar, L., Wang, L., … Levit, R. D. (2017). A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space. JACC: Basic to Translational Science, 2(5), 601–609. https://doi.org/10.1016/j.jacbts.2017.06.003
Mendeley helps you to discover research relevant for your work.