Mechanisms of endogenous nitrosation

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Abstract

Endogenous formation of N-nitroso compounds has been demonstrated in both humans and experimental animals. The extent of this process has been estimated by measurement of urinary N-nitrosoproline and has been shown to be modulated by dietary precursors and inhibitors. It is now also recognized that other (non-gastric) pathways of endogenous nitrosation, including those catalysed by bacteria and mammalian cells, may exist. The mammalian cell catalysed pathway utilizes arginine as a precursor for the nitrosating agent and may occur in macrophages or endothelial cells. The estimated contribution of this pathway to normal basal endogenous nitrosation is approximately 20 nmol of N-nitrosoproline/day.

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Leaf, C. D., Wishnok, J. S., & Tannenbaum, S. R. (1989). Mechanisms of endogenous nitrosation. Cancer Surveys. https://doi.org/10.1007/978-1-4757-9640-7_67

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