Here, we discuss Systems Genetics applications for systematic evaluation of candidate causal genes together with follow-up bioinformatics pathway analysis. The aim of this chapter is to illustrate analytic procedures and we provide examples in the context of Type 1 diabetes (T1day), the risk of which is conferred by over 60 loci. We also describe the Type 1 Diabetes Systems Genetics website and provide a guide for its use and application to other diseases.
CITATION STYLE
Ram, R., & Morahan, G. (2017). Using systems genetics to understanding the etiology of complex disease. In Methods in Molecular Biology (Vol. 1488, pp. 597–606). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6427-7_29
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