Sepsis causes unacceptably high amounts of deaths worldwide. It is a huge unmet medical need, and new therapeutic interventions for sepsis and septic shock are urgently needed. By studying the mechanism by which a bacterial protein undermines the inflammatory function of macrophages, Kim et al, in the last issue of EMBO Molecular Medicine, have developed a new therapeutic protein drug, which appears to have very promising protective activities in a well-validated and aggressive polymicrobial sepsis model in mice. The chimeric protein is thought to limit macrophage inflammation while activating phagocytosis, and so, it hits two macrophage pathways at once.
CITATION STYLE
Vanderhaeghen, T., Wallaeys, C., & Libert, C. (2021). Turning a pathogen protein into a therapeutic tool for sepsis. EMBO Molecular Medicine, 13(1). https://doi.org/10.15252/emmm.202013589
Mendeley helps you to discover research relevant for your work.