The structure of a coumarin derivative related to the carcinogen benz[a]anthracene

Abstract

The three-dimensional structure of 3-methyl-2H-anthra-[1,2-b]pyran-2-one, an anticarcinogenic coumarin related to the carcinogen benz[a]anthracene, has been determined by X-ray diffraction techniques. The molecule, apart from hydrogen atoms in the methyl group, is flat, the maximum deviation from its least squares best plane being 0.13 Å. The carbonyl C = O bond length is normal [1.206(1) Å] and the bonding throughout the molecule indicates localization of double bonds within the coumarin ring, but some delocalization of electrons in the other rings. Molecules pack in planes parallel to each other, the coumarin ring oxygen atom lying between two aromatic rings of other coumarin molecules. The bulky methyl groups are not involved in such stacking, while the carbonyl groups attract C-H groups in neighboring molecules by way of C-H···O interactions. These are the types of interactions that such coumarins could make if they bound to hydrophobic areas in biological macromolecules.