Uterine myomas and histopathology

Abstract

The uterine leiomyoma or fibroid is one of the most common tumours in females, mostly asymptomatic, with an incidence of 22-77 %, typically occurring in the fourth and fifth decade of life, perhaps related to the general changes in the hormonal regime at this age. Recent genetic analysis has associated variants in BET1L and TNRC6B with the volume of leiomyomata [1]. Associations with African ethnicity, with the levels of per oestrogen and progesterone receptors, with regulatory mechanisms and their metabolism, and vitamin D deficiency have all been studied [2]. The correlation with the onset of menarche also seems important as each year of its delay is inversely correlated with the number and size of the tumours [3]. Symptoms are related to the number and size of the lesion: a sense of heaviness, compression of near organs and bleeding.