Bioreactor Systems for Producing Antibody from Mammalian Cells

Abstract

As the market demand for high quality monoclonal antibodies (mAbs) increases, the production of these biomolecules must meet these demands. In order to produce these complex biomolecules, researchers continue to evolve the design configurations of bioreactors to achieve the goals of easier scale-up, tighter con- trol of the process parameters, and/or reductions in operational costs. This chapter reviews the current reactor technologies for producing mAbs using either suspen- sion and anchorage-dependent cell lines, including any advantages and disadvantage of each. 2.1