The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding

Abstract

Background: Synaptotagmin 1 is the Ca2+ sensor for neuronal exocytosis. Results: The juxtamembrane linker of synaptotagmin 1 is oligomerized through a glycine zipper motif, and this interaction controls the activity of synaptotagmin 1. Conclusion: Structural modifications in the linker alter the activity of synaptotagmin 1. Significance: The oligomerization of synaptotagmin 1 may control the organization at the focal site of fusion. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.