Abstract
Fagaronine derivatives syntheses were optimized and their effect on PC3 androgen-independent prostate cell line was evaluated. An assessment of the lipophilicity of the benzo[c]phenanthridine derivatives was achieved at pH 7.4 and et 6.7 by determining log D.
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Vanquelef, E., Hélesbeux, J. J., Duval, O., Debiton, E., Barthomeuf, C., Jarry, C., … Richomme, P. (2007). Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fegaronine derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 22(5), 647–654. https://doi.org/10.1080/14756360701485901
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