Highly efficient, environment-friendly, one-pot synthesis of 2-substituted 4-formylimidazoles from 4-acylaminoisoxazoles

Abstract

A highly efficient and environment-friendly one-pot synthesis of 2-substituted 4-formylimidazoles was accomplished. Raney nickel catalyzed hydrogenation of 4-acylaminoisoxazoles in ethanol, followed by sodium hydroxide promoted recyclization of the ring-opened intermediates, afforded the functionalized imidazoles.