OBJECTIVE: To evaluate the evolution of clinical outcomes in children with bronchiolitis who used a high-flow nasal cannula, and to determine after long of non-clinical improvement the therapy should be discontinued, and treatment should be escalated to other forms of ventilatory support. METHODS: An observational retrospective study of infants with bronchiolitis who used a high-flow nasal cannula. Patients were divided into two study groups according to success or failure of high-flow nasal cannula therapy, namely the Success Group and the Failure Group. The main demographics and clinical variables were assessed 30 minutes and 6 hours after initiating therapy until removal of the high-flow nasal cannula. RESULTS: A total of 83 children were studied and 18 children (21.7%) failed therapy. Among subjects with successful therapy, a significant decrease in respiratory rate (p<0.001), and a significant increase in peripheral oxygen saturation (p<0.001) were observed within 30 minutes. The Success Group was significantly different from the Failure Group after 6 hours, for both respiratory rate (p<0.01) and peripheral oxygen saturation (p<0.01). CONCLUSION: The absence of clinical sign improvement within 30 minutes and for up to a maximum of 6 hours can be considered as failure of the high-flow nasal cannula therapy. If this time elapses with no improvements, escalating to another type of ventilatory support should be considered.
CITATION STYLE
Nascimento, M. S., Quinto, D. E. R., Zamberlan, G. C., Santos, A. Z. D., Rebello, C. M., & Prado, C. do. (2021). High-flow nasal cannula failure: can clinical outcomes determine early interruption? Einstein (Sao Paulo, Brazil), 19, eAO5846. https://doi.org/10.31744/einstein_journal/2021AO5846
Mendeley helps you to discover research relevant for your work.