Modelo biofísico bidimensional que simula el efecto ablativo focalizado de tejido renal cancerígeno a través de radiofrecuencia y nanopartículas ferromagnéticas

Abstract

A bi-dimensional biophysical model to simulate a selective ablative effect in renal cancer was designed and tested. The model involves symmetrical regions of tumor/healthy renal tissue, a single circular coil to generate an alternating magnetic field in the microwave range and the presence of magnetic nanoparticles in the tumor region. The bi-dimensional biophysical model was solved by a finite element technique on the basis of electromagnetic and heat transfer considerations. The simulation produced induced current densities and surfaces of temperature gradients in tumor/healthy renal tissues with and without nanoparticles presence. The induced current density in the tumoral region increased as a function of the nanoparticles presence and was manifested by an increase in the temperature gradient. The simulation results showed that the radio-frequency exposition of renal tumor tissue influenced by magnetic nanoparticles has the potential to being a selective thermal ablation technique for renal cancer therapy. © Springer-Verlag Berlin Heidelberg 2007.