We examined the effect of albumin administration on L-tryptophan (Trp) levels in the serum and tissues of rats with puromycin aminonucleoside (PAN)-induced nephrosis. PNA-injected rats showed increased urinary protein and serum non-esterified fatty acids levels and decreased serum albumin level at 8 days after the injection. The nephrotic rats showed a decrease in total serum Trp level and increases in free serum Trp and liver and kidney Trp levels but no change in urinary Trp level. At 5 rain after intravenous injection of bovine serum albumin, the nephrotic rats had serum albumin concentration similar to the level of non-nephrotic rats and showed a recovery of decreased total serum Trp with the reduction of increased free serum Trp and liver Trp.
CITATION STYLE
Sasaki, E., Ohta, Y., & Ishiguro, I. (2000). Effect of albumin administration on L-tryptophan levels in the serum and tissues of rats with puromycin aminonucleoside-induced nephrosis. In Advances in Experimental Medicine and Biology (Vol. 467, pp. 341–346). https://doi.org/10.1007/978-1-4615-4709-9_44
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