Past Decade Work Done on Cubosomes and its Factorial Design: A Fast Track Information for Researchers

Abstract

The objective  of this review  is to explore  the past work done on Cubosomes  as drug delivery  systems  by factorial  design. Cubosomes  are Nanoparticulate  systems  made of amphiphilic  lipids at a certain percentage,  known  as liquid crystals.  They have tightly packed  honeycomb  structures  twisted  into  3D  bilayers.  Cubosomes  can  capture  all  categories  of  the  lipophilic,  hydrophilic,  and amphiphilic  substances  irrespective  of their affinity, by that they fit for delivering all range of drugs with ease. Many works in recent days are concentrating  on Cubosomes  for drug delivery, as it suits all ranges of drugs without much difficulty. Cubosomes  acts as a carrier in drug  delivery  for a wide range  of drugs  and protects  them  from  degradation  issues  like hydrolysis,  oxidation,  and others.  Moreover, numerous  studies  have established  the benefits  of Cubosomes  in nanotechnology,  prolonged-release, and also enhanced  bioavailability. This article reviews about the past work done on Cubosomes using factorial design. Additionally,  many studies need to be performed for the  optimization  of  Cubosomes  for  artificial  cells,  and  biosensors,  etc.  Moreover,  the  rational  design  of  Cubosomes  for  biomedical applications need to be developed. A widespread literature assessment revealed that many reviews and research attempts were made on Cubosomes,  but no review article is still available in bringing the attempts  made on Cubosomes  by factorial design on a single platform. The  factorial  approach  is  used  to  optimize  the  formulation,  which  is  acceptable  and  used  in  the  current  scenario  in  optimizing  the formulations.  So,  the  authors  made  widespread  work  by  referring  to peer-review  journals,  periodicals,  magazines,  and  succeeded  in bringing work done on Cubosomes  in the last ten years by using factorial design. The study concludes and gives a quick reference to the young researchers to get literature on earlier successive attempts done on Cubosomes by factorial design.