Pathophysiology and treatment of patients with globus sensation - From the viewpoint of esophageal motility dysfunction-

15Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

Abstract

"Globus sensation" is often described as the sensation of a lump in the throat associated with dry swallowing or the need for dry swallowing, which disappears completely during eating or drinking and for which no organic cause can be established. Due to the uncertain etiology of "globus sensation", it remains difficult to establish standard treatment strategies for affected patients. Lately most attention has been focused on gastroesophageal reflux disease and several reports have indicated that there is a close relationship between esophageal acid reflux and globus sensation. Nowadays, empirical therapy with a high dose of a proton pump inhibitor (PPI) is considered to be indicated for patients with globus sensation, after excluding organic diseases such as pharyngeal cancer, Zenker's diverticulum, or thyroid enlargement. If patients are nonresponsive to PPI therapy, evaluation of esophageal motility should be done. In our recent study, 47.9% had abnormal esophageal motility, with the most common esophageal motility abnormality being an ineffective esophageal motility in PPI-resistant patients with globus sensation. This suggests that prokinetics alone or adding prokinetics to PPI should be the treatment to be considered, although few studies have investigated the efficacy of prokinetics in the treatment of patients with globus sensation. If patients without any esophageal motility dysfunctions are nonresponsive to PPI therapy, either cognitive-behavioral therapy, anti-depressants, or gabapentin could be helpful, although further well-designed, randomized controlled large-scale studies will be necessary to determine the effectiveness of each treatment strategy on patients with globus sensation.

References Powered by Scopus

The Montreal definition and classification of gastroesophageal reflux disease: A global evidence-based consensus

3211Citations
N/AReaders
Get full text

U. S. Householder survey of functional gastrointestinal disorders - Prevalence, sociodemography, and health impact

2022Citations
N/AReaders
Get full text

Altered rectal perception is a biological marker of patients with irritable bowel syndrome

940Citations
N/AReaders
Get full text

Cited by Powered by Scopus

A Mixed-Methods Study of Patient Views on Reflux Symptoms and Medication Routines

25Citations
N/AReaders
Get full text

Esophageal Manometry, pH Testing, Endoscopy, and Videofluoroscopy in Patients With Globus Sensation

13Citations
N/AReaders
Get full text

A Comparative Assessment of the Diagnosis of Swallowing Impairment and Gastroesophageal Reflux in Canines and Humans

7Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Manabe, N., Tsutsui, H., Kusunoki, H., Hata, J., & Haruma, K. (2014). Pathophysiology and treatment of patients with globus sensation - From the viewpoint of esophageal motility dysfunction-. Journal of Smooth Muscle Research, 50(1), 66–77. https://doi.org/10.1540/jsmr.50.66

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

69%

Lecturer / Post doc 2

13%

Researcher 2

13%

Professor / Associate Prof. 1

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 15

60%

Psychology 6

24%

Nursing and Health Professions 3

12%

Chemistry 1

4%

Article Metrics

Tooltip
Mentions
References: 1

Save time finding and organizing research with Mendeley

Sign up for free