Three Different Co-existing α-Thalassemia Mutations and Sickle Cell Disease in a Pregnant Woman

Abstract

Thalassemia is the most frequent single-gene defect and overwhelmingly effects prenatal patients in Iran; the condition is caused by a diverse range of mutations. We discuss an extremely rare combination of α-globin gene disease and sickle cell trait. This combination may explain a mild form of thalassemia that presents with moderate anemia.