Lipase-mediated amidation of anilines with 1,3-diketones via C–C bond cleavage

Abstract

In this work, an efficient and green lipase-mediated technique has been mined for the amidation of anilines with 1,3-diketones via C–C bond cleavage. Under the optimal conditions, high yields (64.3%–96.2%) could be obtained when Novozym 435 was used as the catalyst. Furthermore, Novozym 435 exhibited a satisfying reusability and more than 80% of yield can be obtained after seven cycles. This work provides a more rapid and mild strategy for amide synthesis with high yield and expands the application of enzyme in organic synthesis.