About 80-90 % of gastric cancer appears as sporadic form, and 10-20 % with a familial setting; however, considering the different worldwide countries, this frequency appears extremely variable. In high risk-area for gastric tumors this incidence results higher than in low-risk zones. Conversely, the frequency of CDH1 germline mutations is contrasting with the incidence of familial gastric carcinoma. Exploring these considerations, in high-risk area it seems that environmental factors exercise a stronger mechanism in the familial gastric carcinogenesis. This data could open new approaches in the gastric cancer prevention test; before to candidate a proband for the CDH1 genetic screening, geographic variability, alongside the family history should be considered.
CITATION STYLE
Corso, G., & Marrelli, D. (2013). Frequency of familial gastric cancer. In Spotlight on Familial and Hereditary Gastric Cancer (pp. 11–18). Springer Netherlands. https://doi.org/10.1007/978-94-007-6570-2_2
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