The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary microvascular disease

Abstract

Background: As a novel marker of insulin resistance, the ratio of triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) has been recently reported to be related to the occurrence of coronary artery diseases. However, no research has been conducted to probe whether the TG/HDL-C ratio is associated with the occurrence of coronary microvascular disease (CMVD). Aim: This study investigates the association between the TG/HDL-C ratio and the occurrence of CMVD. Methods: This study included 175 patients diagnosed with CMVD in the Department of Cardiology of our hospital from October 2017 to October 2021 as the study group and 175 patients with no chest pain, no history of cardiovascular disease and drug use, and negative results of exercise treadmill testing as the non-CMVD group. The clinical data of the two groups were compared. In addition, the risk factors of CMVD were analyzed with logistic regression, and the efficacy of independent risk factors in predicting CMVD was analyzed with a receiver operating characteristic (ROC) curve. Results: Compared with those in the non-CMVD group, the proportion of females, the incidence of hypertension and type 2 diabetes, the level of platelet count, TG, and C-reactive protein, and the ratio of TG/HDL-C were increased in the CMVD group, accompanied by decreased levels of albumin and HDL-C (P < 0.05). Logistic regression results revealed C-reactive protein (the area under the ROC curve [AUC] value: 0.754; 95% confidence interval [CI]: 0.681–0.827), sex (the AUC value: 0.651; 95%CI: 0.571–0.730), albumin (the AUC value: 0.722; 95%CI: 0.649–0.794), and TG/HDL-C ratio (the AUC value: 0.789; 95%CI: 0.718–0.859) as the independent risk factors of CMVD. Conclusion: The TG/HDL-C ratio is an independent risk factor for the occurrence of CMVD.