Simultaneous voltammetric determination of antihypertensive drugs amlodipine and atenolol in pharmaceuticals using a cathodically pretreated boron-doped diamond electrode

Abstract

The simultaneous voltammetric determination of antihypertensive drugs amlodipine besylate (AML) and atenolol (ATN) using a cathodically pretreated boron-doped diamond electrode (CP-BDDE) is reported for the first time. The anodic peak potentials of AML and ATN at a CP-BDDE were found to be 0.727 and 1.32 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in phosphate buffer (pH 7.0), respectively, by cyclic voltammetry. It was observed that the CP-BDDE possesses improved performance for the simultaneous determination of AML and ATN when compared to other carbon-based electrodes in these conditions. Using square-wave voltammetric technique, the obtained analytical curves were linear in the concentration range from 2.9-33 μmol L-1 for AML and 9.8-190 μmol L-1 for ATN, with limits of detection of 0.17 and 0.22 μmol L-1 , respectively. The proposed method was successfully applied to the simultaneous determination of AML and ATN in pharmaceutical samples.