Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key molecule. Provocation experiments have demonstrated that intravenous CGRP infusion induces migraine-like attacks in migraine with and without aura patients. In addition, these studies have revealed a heterogeneous CGRP response, i.e., some migraine patients develop migraine-like attacks after CGRP infusion, while others do not. The role of CGRP in human migraine models has pointed to three potential sites of CGRP-induced migraine: (1) vasodilation via cyclic adenosine monophosphate (cAMP) and possibly cyclic guanosine monophosphate (cGMP); (2) activation of trigeminal sensory afferents, and (3) modulation of deep brain structures. In the future, refined human experimental studies will continue to unveil the role of CGRP in migraine pathogenesis.
CITATION STYLE
Ashina, H., Schytz, H. W., & Ashina, M. (2019). CGRP in human models of migraine. In Handbook of Experimental Pharmacology (Vol. 255, pp. 109–120). Springer New York LLC. https://doi.org/10.1007/164_2018_128
Mendeley helps you to discover research relevant for your work.