Abstract
Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.
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CITATION STYLE
Kohno, J., Nishio, M., Kawano, K., Nakanishi, N., Suzuki, S. I., Uchida, T., & Komatsubara, S. (1996). TMC-1 A, B, C and D, new antibiotics of the manumycin group produced by Streptomyces sp.: Taxonomy, production, isolation, physico-chemical properties, structure elucidation and biological properties. Journal of Antibiotics, 49(12), 1212–1220. https://doi.org/10.7164/antibiotics.49.1212
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