Analytical method development and validation for the estimation of Naproxen using RP-HPLC

Abstract

A simple and precise method was developed for estimating Dasatinib. The method was found to be specific and precise. The separation was attained on Acquity CSH C18 Column (150*2.0mm & 1.5µm) and linearity was achieved in the concentration rage of 50µg/ml to 250µg/ml of Dasatinib with correlation coefficient 0.99. The percent recovery from the assay was found to be 99.79% for Dasatinib. Limit of detection and quantitation for Dasatinib were within the acceptable range. From the stability studies, the percentage variation was less than 10.0% which is the desired criteria. Therefore, this method can be adopted to estimate Dasatinib in other pharmaceutical formulations.