Aflatoxins and kwashiorkor: A study in Sudanese children

90Citations
Citations of this article
48Readers
Mendeley users who have this article in their library.

Abstract

Blood and urine samples from 252 Sudanese children were investiated for their aflatoxin content by high-performance liquid chromatography. The children comprised 44 with kwashiorkor, 32 with marasmic kwashiorkor, 70 with marasmus, and 106 age-matched, normally nourished controls. Aflatoxins were detected more often and at higher concentrations in sera from children with kwashiorkor than in the other malnourished and control groups. Aflatoxicol, a metabolite of aflatoxins B1 and B2, was detected in the sera of children with kwashiorkor and marasmic kwashiorkor but not in the controls and only once in a marasmic child. The difference between children with kwashiorkor or marasmic kwashiorkor and those in the control or marasmus groups was significant. Urinary aflatoxin was most often detected in children with kwashiorkor but their mean concentration was lower than in the other groups. Aflatoxicol was not detected in urine in any group. These findings suggest either that the children with kwashiorkor have a greater exposure to aflatoxins or that their ability to transport and excrete aflatoxins is impaired by the metabolic derangements associated with kwashiorkor. The presence of aflatoxicol in the sera of children with kwashiorkor but not in the others suggests a difference in metabolism between the two groups. Further studies are needed, and measurement of aflatoxins in the food eaten by these children is already underway.

Cite

CITATION STYLE

APA

Hendrickse, R. G., Coulter, J. B. S., Lamplugh, S. M., Macfarlane, S. B., Williams, T. E., Omer, M. I., & Suliman, G. I. (1982). Aflatoxins and kwashiorkor: A study in Sudanese children. British Medical Journal, 285(6345), 843–846. https://doi.org/10.1136/bmj.285.6345.843

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free