Modeling viral load response in long-term HIV dynamics is important for AIDS clinical study. It allows one to examine how a patient recuperates for an antiviral treatment. This paper investigates a discretization approach to the viral load based on a long-term HIV dynamic model. We propose a two-stage nonparametric procedure for estimating the viral load and the time-varying new productive virus. Simulation study shows that the proposed estimated methods are efficient and powerful for fitting long-term viral load measurements. © Springer-Verlag Berlin Heidelberg 2005.
CITATION STYLE
Chen, J., Zhang, J. T., & Wu, H. (2005). Discretization approach and nonparametric modeling for long-term HIV dynamic model. In Lecture Notes in Computer Science (Vol. 3483, pp. 519–527). Springer Verlag. https://doi.org/10.1007/11424925_55
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