Total Synthesis of Ardisiaquinone A, A Potent 5-Lipdxygenase Inhibitor, Isolated from Ardisia Sieboldii, and Degree of 5-Lipoxygenase Inhibitory Activity of its Derivatives

Abstract

Ardisiaquinone A (1), isolated as a potent 5-lipoxygenase inhibitor from the woods of Ardisia sieboldii, has been synthesized efficiently via a cross-coupling reaction between the yne 5 and the iodide 6 derived from the common intermediate 4. Inhibitory activity for 1 and its derivatives is also reported. © 1994, The Pharmaceutical Society of Japan. All rights reserved.