Obtaining biocompatible polymeric scaffolds loaded with calcium phosphates through the digital light processing technique

Abstract

In the present work, scaffolds with gyroid TPMS geometry were obtained from a commercial resin of acrylic nature loaded with 0.5% and 1% w/V of calcium phosphate nanoparticles through DLP. The scaffolds obtained presented Young's Modulus between 300 and 400 MPa, which makes them suitable for bone applications. The surface treatment by oxygen plasma carried out on the scaffolds resulted in a notable improvement in the wettability of the surfaces, which favours cell adhesion on the surface of the materials. The in vitro bioactivity assay conducted on the resin/calcium phosphate particles composite material showed that an apatitic layer forms on the surface of the samples from the third day of exposure to simulated body fluid (SBF), indicating that the composite material has in vitro bioactive behaviour. Biological tests demonstrated that the material is not cytotoxic and favours cell adhesion and that the gyroid geometry promotes cell proliferation. Graphical abstract: (Figure presented.)