Redesignation of a purported P1.15 subtype-specific meningococcal monoclonal antibody as a P1.19-Specific reagent

Abstract

Two reference monoclonal antibodies against the meningococcal P1.15 subtype PorA, MN3C5C and 2-1P1.15, showed only partial concordant recognition of meningococcal isolates. Cyanogen bromide cleavage of P1.19,15 PorA, peptide mapping, and sequencing ofporA regions demonstrated that 2-1-P1.15 was specific for subtype P1.19, and henceforth it is to be redesignated as 2- 1-P1.19.