How pectin play a role in histological changes by monosodium glutamate (Msg) in the ovary of mice?

Abstract

Background and Objective: The effects of pectin from the natural vitamins and herbs on the ovary of mice induced by monosodium glutamate (MSG) leads to over accumulations in living cells and finally produces cellular toxicity and damage, pectin helps to rapidly reduce this changes. Materials and Methods: Cytotoxicity of monosodium glutamate was investigated histologically by using hematoxylin and eosin (H and E) stains. The animals received (MSG) in drinking water at a dose of 3 g kgG1 b.wt., in drinking water for three weeks. The ovary tissues were subjected to histological and morphological analysis. Results: In female rats treated with a dose of MSG of 3 g kgG1 daily in drinking water clear toxicological effects on the ovary tissue were significantly obtained. The mice were then anesthetized, dissected the ovary samples were taken from female mice and kept in a 10% neutral formalin solution to make tissue slides after that examined under the microscope to see the differences. Sections showed the occurrence of several histopathological changes in the ovary. Conclusion: This study concluded that the effectiveness of pectin therapy on ovarian cells destroyed by the effect of monosodium glutamate, which has proven to be very effective in treating all affected and restoring tissue to normal.