The influence of body mass index (BMI) on susceptibility to anorexia nervosa (AN) is not clear. Recently published genome-wide association (GWA) studies of the general population identified several variants influencing BMI. We genotyped these variants in an AN sample to test for association and to investigate a combined effect of BMI-increasing alleles (as determined in the original GWA studies) on the risk of developing the disease. Individual single nucleotide polymorphisms (SNPs) were tested for association with AN in a sample of 267 AN patients and 1,636 population controls.Alogistic regression for the combined effect of BMI-increasing alleles included 225 cases and 1,351 controls. We found no significant association between individual SNPs and AN. The analysis of a combined effect of BMI-increasing alleles showed absence of association with the investigated condition. The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN. © 2009 Wiley-Liss, Inc.
CITATION STYLE
Brandys, M. K., Van Elburg, A. A., Loos, R. J. F., Bauer, F., Hendriks, J., Van Der Schouw, Y. T., & Adan, R. A. H. (2010). Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 153(2), 695–699. https://doi.org/10.1002/ajmg.b.31026
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