Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

Abstract

Background: Human papillomaviruses (HPVs) are strongly associated with the development of cervical carcinoma, and the distribution of HPV genotypes varies regionally. Methods: To investigate the distribution characteristics of different genotypes of HPV infection in women in Wuhan, China, a total of 13 775 patients were enrolled over 2 years. Results: Of these, 2436 patients were infected with HPVs, and the total infection rate was 17.68%. The infection rate of high-risk HPV (HR-HPV) was significantly higher (13.96%) than that of single low-risk HPV (LR-HPV; 3.72%). Among the HR-HPV infections, the most common genotype was HPV 52 with an infection rate of 4.23%, followed by HPVs 16, 58, 39, and 51. The most common LR-HPV genotype was HPV 81, followed by HPVs 6, 11, and 44. Patients under the age of 25 years were found to have the highest HPV infection rate (P