Supernatural T cells: Genetic modification of T cells for cancer therapy

133Citations
Citations of this article
121Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Immunotherapy is receiving much attention as a means of treating cancer, but complete, durable responses remain rare for most malignancies. The natural immune system seems to have limitations and deficiencies that might affect its ability to control malignant disease. An alternative to relying on endogenous components in the immune repertoire is to generate lymphocytes with abilities that are greater than those of natural T cells, through genetic modification to produce 'supernatural' T cells. This Review describes how such T cells can circumvent many of the barriers that are inherent in the tumour microenvironment while optimizing T-cell specificity, activation, homing and antitumour function. © 2005 Nature Publishing Group.

Cite

CITATION STYLE

APA

Kershaw, M. H., Teng, M. W. L., Smyth, M. J., & Darcy, P. K. (2005, December). Supernatural T cells: Genetic modification of T cells for cancer therapy. Nature Reviews Immunology. https://doi.org/10.1038/nri1729

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free