Transposase-driven rearrangements in human tumors

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Abstract

A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification.

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Mack, S. C., Suzuki, H., & Taylor, M. D. (2017). Transposase-driven rearrangements in human tumors. Nature Genetics, 49(7), 975–977. https://doi.org/10.1038/ng.3908

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