Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing

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Abstract

The avascular nature of cornea tissue limits its regenerative potential, which may lead to incomplete healing and formation of scars when damaged. Here, we applied micro- A nd ultrafine porcine urinary bladder matrix (UBM) particulate to promote type 2 immune responses in cornea wounds. Results demonstrated that UBM particulate substantially reduced corneal haze formation as compared to the saline-treated group. Flow cytometry and gene expression analysis showed that UBM particulate suppressed the differentiation of corneal stromal cells into smooth muscle actin positive (SMA+) myofibroblasts. UBM treatments up-regulated interleukin-4 (IL-4) produced primarily by eosinophils in the wounded corneas and CD4+T cells in draining lymph nodes, suggesting a cross-talk between local and peripheral immunity. Gata1-/-mice lacking eosinophils did not respond to UBM treatment and had impaired wound healing. In summary, stimulating type 2 immune responses in the wounded cornea can promote proregenerative environments that lead to improved wound healing for vision restoration.

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Wang, X., Chung, L., Hooks, J., Maestas, D. R., Lebid, A., Andorko, J. I., … Elisseeff, J. H. (2021). Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing. Science Advances, 7(16). https://doi.org/10.1126/sciadv.abe2635

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