The c-FLIPL cleavage product p43FLIP promotes activation of Extracellular Signal-regulated Kinase (ERK), nuclear factor κb (NF-κB), and caspase-8 and T cell survival

Abstract

Background: c-FLIPL is a regulator of caspase-8 activity in T lymphocytes. Results: Caspase-8 activity is lost upon deletion of c-FLIPL. p43FLIP rescues caspase-8 activity through Raf1, TRAF2, and RIPK1 association, augmenting ERK and NF-κB pathways. Conclusion: The FLIPL cleavage product p43FLIP promotes activation of pathways involved with T cell growth. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.