Heterotaxy syndrome is characterized by a wide variety of cardiac and extracardiac congenital malformations that are primarily induced by disorders of the left-right axis determination during early embryonic development. Prognosis of the disease remains unsatisfactory because the syndrome is often associated with complicated congenital heart diseases. Long-term follow-up of heterotaxy patients, particularly those who underwent Fontan procedure, is now one of the most important issues in pediatric and adult congenital heart disease clinics. Collaborative studies between pediatric cardiologists and basic scientists are essential for improving the prognosis of heterotaxy syndrome.
CITATION STYLE
Shiraishi, I. (2016). Left-right asymmetry and human heterotaxy syndrome. In Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology (pp. 49–56). Springer Japan. https://doi.org/10.1007/978-4-431-54628-3_6
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