Predictive value of IL-18 and SC5b-9 for neurocognitive dysfunction after cardiopulmonary bypass

23Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background. Neurological injury after cardiopulmonary bypass (CPB) continues to be a major problem after cardiac surgery. The aim of this study was to investigate the predictive value of Interleukin-18 (IL-18) and SC5b-9 as biochemical markers of neurocognitive dysfunction after cardiac surgery. Methods. A total of 30 patients undergoing elective cardiac surgery using CPB were recruited. Blood samples were obtained for IL-18 and SC5b-9 concentrations before induction, 24, 48, 72, 96 and 120 h post-CPB and 6 weeks after operation. In addition, patients underwent a standard battery of neuropsychometric tests before operation and at day 5 and 6 weeks after operation. Results. Serum concentration of IL-18, but not SC5b-9, was significantly different between patients with and without neurocognitive dysfunction; serum IL-18 concentration significantly increased in patients with neurocognitive dysfunction (P=0.018). Neurological outcome was significantly dependent on peak difference in IL-18 concentration at day 5 (P=0.033), but not on peak difference in SC5b-9 concentration (P=0.16). Eight patients had neurocognitive dysfunction at day 5 and three had neurocognitive dysfunction at 6 weeks. In a very small number of patients, no significant association was demonstrated between IL-18 or SC5b-9 concentrations and neurocognitive dysfunction at 6 weeks. Conclusions. IL-18 has the potential as a useful marker of neurological dysfunction, requiring further investigation. © The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved.

Cite

CITATION STYLE

APA

Kumar, R. A., Cann, C., Hall, J. E., Sudheer, P. S., & Wilkes, A. R. (2007). Predictive value of IL-18 and SC5b-9 for neurocognitive dysfunction after cardiopulmonary bypass. British Journal of Anaesthesia, 98(3), 317–322. https://doi.org/10.1093/bja/ael366

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free