Thirteen members of mammalian aquaporins have been identified. Initial ten members (AQP-AQP9) are relatively well detailed and their roles are clarified. However, the last three members, AQP10-AQP12, are poorly characterized and little is known about their roles though they were cloned 6 years ago. In this review, we focus on these three AQPs. AQP10 is an aquaglyceroporin while AQP11 and AQP12 belong to a new subfamily, superaquaporins. Knockout mice for these aquaporins are now available. The AQP11 null mouse has a remarkable phenotype, polycystic kidneys, which is neonatally fatal. On the other hand, the absence of the other two affected little. In some animals, AQP10 is even a pseudogene. This review summarizes the current knowledge on these AQPs and will hopefully stimulate future research on the subject. © 2009 Springer Berlin Heidelberg.
CITATION STYLE
Ishibashi, K. (2009). New members of mammalian aquaporins: AQP10-AQP12. Handbook of Experimental Pharmacology. https://doi.org/10.1007/978-3-540-79885-9_13
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