Effect of grelin on TRX expression in chronic heart failure tissue: A protocol of systematic review and meta-analysis

Abstract

Background:The aim of this study is to explore the effect of grelin on TRX expression (TRXE) in chronic heart failure tissue (CHFT).Methods:We will search electronic databases from inception to the March 1, 2020 in MEDLINE, EMBASE, Cochrane Library, CINAHL, PEDro, the Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. We will not apply any limitations to the language and publication status. Any randomized controlled trials (RCTs) that studied the effect of grelin on TRXE in CHFT will be included. Study quality will be checked by Cochrane risk of bias and evidence quality will be appraised by Grading of Recommendations Assessment Development and Evaluation. All extracted data will be analyzed by RevMan 5.3 Software.Results:This study will summarize the present RCTs to assess the effect of grelin on TRXE in CHFT.Conclusion:The results of this study will provide conclusive evidence of the effect of grelin on TRXE in CHFT.Systematic review registration:INPLASY202040078.