A complex role for calcium signaling in colorectal cancer development and progression

35Citations
Citations of this article
48Readers
Mendeley users who have this article in their library.

Abstract

Clinical data suggest that many malignant cancers are associated with hypercalcemia. Hypercalcemia can facilitate the proliferation and metastasis of gastric and colon tumors, and has been considered a hallmark of end-stage disease. However, it has also been reported that dietary calcium or Vitamin D supplementation could reduce the risk of many types of cancers. In particular, the intestines can absorb considerable amounts of calcium via Ca2+-permeable ion channels, and hypercalcemia is common in patients with colorectal cancer. Thus, this review considers the role of calcium signaling in the context of colorectal cancer and summarizes the functions of specific regulators of cellular calcium levels in the proliferation, invasion, metastasis, cell death, and drug resistance of colorectal cancer cells. The data reveal that even a slight upregulation of intracellular Ca2+ signaling can facilitate the onset and progression of colorectal cancer, while continuous Ca2+ influx and Ca2+ overload may cause tumor cell death. This dual function of Ca2+ signaling adds nuance to the debate over the hallmarks of colorectal cancer, and may even provide new directions and strategies for clinical interventions.

References Powered by Scopus

A model for receptor-regulated calcium entry

2236Citations
N/AReaders
Get full text

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

1959Citations
N/AReaders
Get full text

Store-operated calcium channels

1859Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The crosstalk between pattern-recognition receptor signaling and calcium signaling

41Citations
N/AReaders
Get full text

Calcium-based nanotechnology for cancer therapy

21Citations
N/AReaders
Get full text

Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention

21Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Wang, W., Yu, S., Huang, S., Deng, R., Ding, Y., Wu, Y., … Lu, Y. (2019). A complex role for calcium signaling in colorectal cancer development and progression. Molecular Cancer Research. American Association for Cancer Research Inc. https://doi.org/10.1158/1541-7786.MCR-19-0429

Readers over time

‘19‘20‘21‘22‘23‘240481216

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

65%

Researcher 4

24%

Professor / Associate Prof. 2

12%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 7

50%

Medicine and Dentistry 4

29%

Engineering 2

14%

Pharmacology, Toxicology and Pharmaceut... 1

7%

Save time finding and organizing research with Mendeley

Sign up for free
0