We have previously demonstrated that eating glutinous brown rice (GBR) for 1 day or 8 weeks was well accepted and improved glycemic control in patients with type 2 diabetes. The present study evaluated whether eating GBR could also improve glucose metabolism in subjects without diabetes. A prospective 6-week, single-center, randomized, open-label, parallel-group study was carried out in subjects receiving annual medical checkup at our hospital. A total of 42 subjects were randomly assigned to continue their regular diet (RD group) or to switch GBR twice a day (GBR group). The primary outcome was the change in the serum concentration of 1,5-Anhydroglucitol (1,5-AG) from baseline after the 6-week dietary intervention. One subject was excluded from the analysis because of a traffic accident. After 6 weeks, the serum 1,5-AG was significantly increased in the GBR group and the mean treatment difference (GBR group-RD group) was 1.1 μg/mL (95% CI: 0.6 to 1.6, p=0.022). Body mass index decreased significantly in both groups, with no significant difference between them (p=0.210). There were no changes in fasting plasma glucose, fasting insulin, or eating behavior. Intake of GBR for 6 weeks significantly increased serum 1,5-AG in Japanese subjects without diabetes. The increase of 1,5-AG may have been due to the alleviation of postprandial hyperglycemia, which could be effective for the primary prevention of diabetes.
CITATION STYLE
Nakayama, T., Nagai, Y., Yasunaka, Y., Uraguchi, T., Wada, Y., Sone, M., & Tanaka, Y. (2020). Effect of eating glutinous brown rice twice a day for 6 weeks on serum 1,5-Anhydroglucitol in japanese subjects without diabetes. Journal of Nutrition and Metabolism, 2020. https://doi.org/10.1155/2020/8847781
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