Vascular endothelial growth factor (VEGF) is known to be a mediator of angiogenesis and vascular permeability. A cystic component and hemorrhage are often found in pituitary adenomas. In the present study we assess the VEGF expression based on immuno-histochemical examinations in 48 pituitary adenomas. All the adenomas showed some VEGF immunoreactivily mainly in the cytoplasm of tumor cells. Of the 48 adenoma-cases, 16 cases had a strong VEGF immunoreactivity, 26 cases had a moderate one, and 6 cases had a weak one. On the MR images, a cystic component was found in 16 cases (33.3%), and a hemorrhage was found in 18 cases (37.5%). The VEGF immunoreactivity had a significant relationship with the cystic component but neither the hemorrhage, size, recurrence, or HE classification. These findings suggest that VEGF might play a potential role in the pathogenesis of cystic formation in pituitary adenomas. © Springer-Verlag 2003.
CITATION STYLE
Fukui, S., Nawashiro, H., Otani, N., Ooigawa, H., Yano, A., Nomura, N., … Shima, K. (2003). Vascular endothelial growth factor expression in pituitary adenomas. Acta Neurochirurgica, Supplementum, (86), 519–521. https://doi.org/10.1007/978-3-7091-0651-8_106
Mendeley helps you to discover research relevant for your work.